LC-MS/MS Analysis

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Description

LRRK2 kinase inhibition reduces the intracellular response to haloperidol, we predicted that hyperactive mutant LRRK2 should mimic haloperidol-induced molecular alterations in WT mice. To test this hypothesis, we conducted unbiased proteomic characterization in the striatum, using mice expressing the G2019S (GS) mutation of LRRK2, which increases its kinase activity.

Identifier (DOI)

10.17504/protocols.io.81wgbr1kylpk/v1

Team

Team Awatramani

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

Meet the Authors

Chuyu Chen, PhD

Key Personnel: Team Awatramani,

Northwestern University
Loukia Parisiadou, PhD

Co-PI (Core Leadership): Team Awatramani,

Northwestern University (Chicago)

LC-MS/MS Analysis

Output Details

Meet the Authors

Chuyu Chen, PhD

Loukia Parisiadou, PhD

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