Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons

Description

In this study, Hwang, Roth, et al. find that motor learning recruits a population of engram neurons in the motor cortex that are reactivated during task performance. Motor learning leads to selective remodeling of dendritic spines and strengthening of outputs to the striatum of M1 engram neurons.

Identifier (DOI)

10.1016/j.neuron.2022.06.006

Tags

Cortical
Motor symptoms
Original Research
Striatum

Team

Team Surmeier

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

Meet the Authors

Fuu Jiun Hwang, PhD

Key Personnel: Team Surmeier,

Stanford University
Richard Roth, PhD

Key Personnel: Team Surmeier,

Stanford University
Yu-Wei Wu
Yue Sun, PhD

Key Personnel: Team Surmeier,

Stanford University
Destany K. Kwon
Yu Liu
Jun Ding, PhD

Collaborating PI: Team Surmeier,

Stanford University

Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons

Output Details

Meet the Authors

Fuu Jiun Hwang, PhD

Richard Roth, PhD

Yu-Wei Wu

Yue Sun, PhD

Destany K. Kwon

Yu Liu

Jun Ding, PhD

Related Research

Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons Dataset

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Datasets and Key Resources Table used in Do, Quyen B. et al. (2023) “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation”