MS LysoIP SH-SY5Y

We identify dozens of novel lysosomal proteins across brain cells, including those linked to disease. Notably, we found that SLC45A1, mutations in which cause a monogenic neurological disease, is a neuron-specific lysosomal protein. Here, we characterize the change in proteomic composition of the lysosome upon SLC45A1 KO, under fed and starved (serum deprived) conditions, as well as global whole cell proteomic changes. Note: Raw file names do not match real conditions. For proper condition assignment, please check the conditions table.