Multi-electrode array (MEA)

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Output Details

Description
Procedure for multi-electrode array used in "Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function"
Identifier (DOI)
10.17504/protocols.io.j8nlkonj6v5r/v1
Tags
  • Multi-electrode array
Team
Team Gradinaru
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

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Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only a fraction of α-syn is phosphorylated at this site, and most…

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Mouse Stereotaxic Surgery

This protocol describes the steps for performing stereotaxic surgery in mice. It is applicable to intracranial injections (e.g. virus, drug) and placement of implants (e.g. optical fibers, electrode arrays) into targeted regions of mouse brains.

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Multi-electrode array recordings

MEA recordings in acute slices

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