LRRK2-G2019S affects iron homeostasis in macrophages by dysregulating iron-related proteins. This leads to impaired ferritinophagy, increased oxidative stress, and cell death, highlighting LRRK2's role in iron regulation in Parkinson's Disease.
HyDrop protocol enables single-cell sequencing for RNA and chromatin accessibility. Generated over 7996 single-cell profiles for ATAC-seq and 9508 for RNA-seq in mouse cortex. Protocol validated on low-input samples from Drosophila brain.
