Population fraction of Parkinson’s disease attributable to preventable risk factors

Description

Parkinson’s disease is the fastest growing neurologic disease with seemingly no means for prevention. Intrinsic risk factors (age, sex, genetics) are inescapable, but environmental factors are not. We identified repeated blows to head in sports/combat as a potential new risk factor. 23% of PD cases in females were attributable to pesticides/herbicides exposure, and 30% of PD in males were attributable to pesticides/herbicides, military-related chemical exposures, and repeated blows to the head, and therefore could have potentially been prevented.

Identifier (DOI)

10.1038/s41531-023-00603-z

Tags

CRN Cloud Platform
Original Research

Team

Team Liddle

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

Meet the Authors

Haydeh Payami, PhD

Co-PI (Core Leadership): Team Liddle,

University of Alabama at Birmingham
Timothy Sampson, PhD

Co-PI (Core Leadership): Team Liddle,

Emory University
Gwendolyn Cohen

Key Personnel: Team Liddle,

University of Alabama at Birmingham
Chad Murchison, PhD

Key Personnel: Team Liddle,

University of Alabama at Birmingham
David Standaert

Key Personnel: Team Sulzer,

University of Alabama at Birmingham
Zachary Wallen, PhD

Key Personnel: Team Liddle,

University of Alabama at Birmingham

Population fraction of Parkinson’s disease attributable to preventable risk factors

Output Details

Meet the Authors

Haydeh Payami, PhD

Timothy Sampson, PhD

Gwendolyn Cohen

Chad Murchison, PhD

David Standaert

Zachary Wallen, PhD

Related Research

Population fraction of Parkinson’s disease attributable to preventable risk factors

Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms

Gut mucosal cells transfer α-synuclein to the vagus nerve