Imbalances in dorsal striatum output in Parkinson's disease are driven by dopamine loss and disrupted acetylcholine signaling. These changes occur in response to dopamine loss, affecting M4 receptors in striatal neurons, crucial for PD progression.
The dataset contained in this repository are the processed data and information used in all the quantifications, tables, and figures associated with the project by Albarran et al 2025 elife.
The software contained in this repository was used to analyze the whole-cell electrophysiology recordings of striatal spiny projection neurons and midbrain dopamine neurons.
