Protocol selection for Kim et al. Cell 2024 V.2

By Tae Wan Kim, PhD, So Yeon Koo, BSc and Lorenz Studer, MD
View Published Protocol

Output Details

Description
Protocol collection for the method section for the publication: "TNF-NF-kB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons" from Kim et al. Cell 2024 The list consists of 13 different protocols. The full publication can be found here: DOI: [10.1016/j.cell.2024.05.030](https://doi.org/10.1016/j.cell.2024.05.030)
Identifier (DOI)
10.17504/protocols.io.kqdg3qmzev25/v2
Tags
  • Cell replacement
  • Cell therapy
  • Human
  • In Vitro
  • In Vivo
  • Intracerebral transplantation
  • iPSC
  • Mouse
Team
Team Studer
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • Tae Wan Kim, PhD

    Key Personnel: Team Studer, 

    Memorial Sloan Kettering Cancer Center

  • So Yeon Koo, BSc

    Key Personnel: Team Studer, 

    Memorial Sloan Kettering Cancer Center

  • Lorenz Studer, MD

    Lead PI (Core Leadership): Team Studer, 

    Memorial Sloan Kettering Cancer Center

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TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons

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Gene expression profile at single cell levels of the cells from the controls and tau P251L Drosophila brain

Tau protein's role in Alzheimer's disease was studied by introducing a human tau mutation into Drosophila using CRISPR. Single-cell RNA sequencing helped identify genes and pathways involved in tauopathy.

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scAlleleExpression: R package for downstream analysis of allele specific expression single cell data

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Aligning Science Across Parkinson's
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