RAW 264.7 LRRK2 KO + HALO-human LRRK2

By Amanda Bentley-DeSousa, PhD and Shawn Ferguson, PhD

Output Details

Description
RAW 264.7 LRRK2 KO + HALO-human LRRK2 cell line
Team
Team De Camilli
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

Related Research

A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage evoked by chemical and pathogenic stimuli. However, the endogenous cellular mechanisms that…

View Article

Dynamic basal ganglia output signals license and suppress forelimb movements

Basal ganglia is fundamental to motor control and dysfunction is linked to motor deficits. Our results demonstrate the existence and function of highly specific and temporally precise movement representations in basal ganglia output circuitry.

View Article

Mouse Stereotaxic Surgery-Arber Lab

This protocol describes the steps for performing stereotaxic surgery in mice. It is applicable to intracranial injections (e.g. virus, drug) and placement of implants (e.g. optical fibers, electrode arrays) into targeted regions of mouse brains.

View Protocol
View More Outputs