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Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model

By Sara Lucas Del Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, MSc, David Chau, Derralynn Hughes, Anthony Schapira, PhD
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Output Details

Description
In the present study, we exploited the SH-SY5Y cell model overexpressing a pro-aggregation form of alpha-synuclein to investigate the efficacy of PIKfyve-mediated lysosomal biogenesis, through TFEB, as potential target for Parkinson therapy.
Identifier (DOI)
10.1101/2023.10.23.563557
Tags
  • 2D cultures
  • Alpha-synuclein
  • Differentiation
  • Lysosomes
Discovery Team
Team Schapira
Program
Collaborative Research Network
Theme
Neuro-Immune Interactions

Meet the Authors

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    Sara Lucas Del Pozo

    External Collaborator

  • User avatar fallback logo

    Giuseppe Uras

    External Collaborator

  • User avatar fallback logo

    Federico Fierli

    External Collaborator

  • User avatar fallback logo

    Veronica Lentini

    External Collaborator

  • Sofia Koletsi, MSc

    Project Manager: Team Schapira, 

    University College London

  • User avatar fallback logo

    David Chau

    External Collaborator

  • User avatar fallback logo

    Derralynn Hughes

    External Collaborator

  • Anthony Schapira, PhD

    Lead PI (Core Leadership): Team Schapira, 

    University College London

Related Research

Datasets and Key Resources Table used in Do, Quyen B. et al. (2023) “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation”

The files found here are associated to Do, Q. et al (2023) study and contain: (a) all source and supplementary data, (b) Key Resources Table, and (c) list of primers.

View Dataset

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

The results highlight the unique utility of modeling striatal neurons in a modular and highly physiological circuit, which is essential to reveal mechanistic insights of the loss of electrical functional integrity in the striata of GBA1 PD patients.

View Article

STC-1 cell culture

Cell culture of STC-1 mouse enteroendocrine cells.

View Protocol
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Aligning Science Across Parkinson's
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