RNA Seq dataset for: α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

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Output Details

Description
Actively transcribed messenger ribonucleic acids (mRNAs) were harvested from SNc dopaminergic neurons in aSYN monomer or PFF-injected mice 12 wpi (weeks post injection) and then subjected to RNASeq analysis. To selectively harvest mRNAs from dopaminergic neurons, DAT-Cre mice were stereotaxically injected with an AAV vector carrying a DIO-RiboTag expression construct
Tags
  • Alpha-synuclein
  • Mouse
  • Postmortem
Team
Team Surmeier and Team Kaplitt
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

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α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Our findings suggest that disruption of mitochondrial function, and the subsequent bioenergetic deficit, is a proximal step in the cascade of events induced by aSYN pathology leading to dysfunction and degeneration of neurons at-risk in PD.

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Elevated brain α-synuclein, phosphorylated-tau, and oxidative stress in mice that survived influenza A pneumonitis

Influenza virus infection does not alter acute lung infection course in mice with Lrrk2 mutations. Surviving mice showed elevated neurodegeneration markers post-infection, suggesting a link between influenza and neurodegenerative diseases in humans.

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Source data for the article “α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice”

α-Synuclein aggregation in mice reduces cortico-amygdala connectivity, leading to impaired social behavior.

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Aligning Science Across Parkinson's
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