During selective autophagy transmembrane cargo receptors can trigger autophagy by recruiting different complexes and utilizing multiple pathways. This flexibility in autophagy initiation has important therapeutic implications.
Lange et al. proposed a model for mitochondrial prohibitin complex with unequal subunit stoichiometry. Data suggests an asymmetric structure, questioning the validity of the proposed model. Care is needed in symmetry imposition in cryo-ET.
