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Tabular data from Mitochondrial Proteostasis Cryo-ET Analysis

By Kenneth Ehses, Jorge P. López-Alonso, Odetta Antico, Yannik Lang , Till Rudack, Abdussalam Azem, Miratul Muqit, Ruben Fernandez-Busnadiego, PhD
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Output Details

Description
Using cryo–electron tomography in human cells, we investigated the structural response of mitochondria to proteostatic stress. Stress induced protein aggregation in the mitochondrial matrix, remodeling of cristae architecture, and a reduction in mitochondrial ribosome complexes. Concomitantly, mitochondrial Hsp60 adopted conformations favoring complexes with its co-chaperone Hsp10, revealing structural adaptations that support mitochondrial proteostasis.
Identifier (DOI)
10.5281/zenodo.17698986
Tags
  • Mitochondria
Discovery Team
Team Harper, Team Alessi
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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    Kenneth Ehses

    External Collaborator

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    Jorge P. López-Alonso

    External Collaborator

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    Odetta Antico

    External Collaborator

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    Yannik Lang

    External Collaborator

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    Till Rudack

    External Collaborator

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    Abdussalam Azem

    External Collaborator

  • Miratul Muqit

    Co-PI (Core Leadership): Team Alessi, 

    University of Dundee

  • Ruben Fernandez-Busnadiego, PhD

    Co-PI (Core Leadership): Team Harper, 

    University of Gottingen

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Aligning Science Across Parkinson's
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