Transcriptomic profiling of human iPSC-derived midbrain astrocytes in ATP13A2 deficiency (c.1306) models

This dataset contains transcriptomic profiling of human iPSC-derived midbrain astrocytes. The study compares Wild Type (WT) astrocytes and ATP13A2 c.1306 loss of function mutants. The objective was to characterize the transcriptional effects of the genotype, specifically focusing on the induction of neuroinflammation and markers of lysosome dysfunction associated with early-onset Parkinson's Disease