Unaltered T cell responses to common antigens in individuals with Parkinson’s disease

Output Details

Preprint April 8, 2022

Published November 25, 2022

Parkinson’s disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).
Tags
  • Neuroscience
  • Original Research

Meet the Authors

  • User avatar fallback logo

    Gregory Williams, PhD

    Key Personnel: Team Sulzer

    La Jolla Institute For Allergy & Immunology

  • User avatar fallback logo

    Kaylin Muskat

  • April Frazier, PhD

    Project Manager: Team Sulzer

    La Jolla Institute For Allergy & Immunology

  • Yaqian (Heather) Xu

    Columbia University Medical Center

  • User avatar fallback logo

    Jose Mateus

  • User avatar fallback logo

    Alba Grifoni

  • User avatar fallback logo

    Ricardo da Silva Antunes

  • User avatar fallback logo

    Daniela Weiskopf

  • User avatar fallback logo

    Amy W. Amara

  • David Standaert

    Key Personnel: Team Sulzer

    University of Alabama at Birmingham

  • User avatar fallback logo

    Jennifer G. Goldman

  • User avatar fallback logo

    Irene Litvan

  • User avatar fallback logo

    Roy Alcalay

  • David Sulzer, PhD

    Lead PI (Core Leadership): Team Sulzer

    Columbia University

  • Cecilia Arlehamn, PhD

    Co-PI (Core Leadership): Team Sulzer

    La Jolla Institute For Allergy & Immunology

  • Alessandro Sette, PhD

    Key Personnel: Team Sulzer

    La Jolla Institute For Allergy & Immunology

Aligning Science Across Parkinson's
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.