Available ASAP-related hPSC collection from Team Studer
By onCollection of human pluripotent stem cell lines consisting of isogenic GBA, LRRK2, SNCA series, KI-reporter lines for TOMM20, b-actin, LAMB1, LAMP1, a-synuclein overexpression lines, and other hPSC resources.
KOLF2.1J DJ1 L166P 1
By onKOLF2.1J DJ1 L166P clone 1. The iPSC line used for the generation of the DJ1 L166P point mutation was from KOLF 2.1 J background (Pantazis et al., 2021)
KOLF2.1J DJ1 L166P 2
By onKOLF2.1J DJ1 L166P clone 2. The iPSC line used for the generation of the DJ1 L166P point mutation was from KOLF 2.1 J background (Pantazis et al., 2021)
H9 ES AAVS1-NGN2 3xFLAG-EEA1 TMEM192-3xHA
By onES cells were modified to create iNeurons expressing EEA1 with a 3xFLAG tag and TMEM192 with 3xHA tag. NEUROG2 was introduced at the AAVS1 locus using CRISPR/Cas9. The cells are derived from human embryonic stem cells at the blastocyst stage.
RAW 264.7 LRRK2 KO + HALO-human LRRK2 (LIR1 mutant) + HA-human GABARAP
By onRAW 264.7 LRRK2 KO + HALO-human LRRK2 (LIR1 mutant) + HA-human GABARAP cell line
RAW 264.7 LRRK2 KO + HALO-human LRRK2 (LIR2 mutant) + HA-human GABARAP
By onRAW 264.7 LRRK2 KO + HALO-human LRRK2 (LIR2 mutant) + HA-human GABARAP cell line
RAW 264.7 LRRK2 KO + HALO-human LRRK2 (LIR1+2 mutant) + HA-human GABARAP
By onRAW 264.7 LRRK2 KO + HALO-human LRRK2 (LIR1+2 mutant) + HA-human GABARAP cell line
PPM1M knockout Mouse Embryonic Fibroblasts (mouse)
By onPPM1M knockout mouse embryonic fibroblasts compared to wild-type littermate controls.
LRRK2 R1441C/PINK1 Double mutant mouse embryonic fibroblasts
By onLRRK2 R1441C/PINK1 double mutant mouse embryonic fibroblasts were studied alongside homozygous mutant and littermatched wild-type cells.
L1-silenced iPSC line (HS1_L1HS-CRISPRi_g1)
By onHuman iPSCs were modified with CRISPRi to target LINE-1 retrotransposons, creating stable cell lines with different genetic backgrounds and guide RNAs. These resources are detailed in Adami et al. (DOI: 10.1016/j.xgen.2025.100979).
L1-silenced iPSC line (HS2_L1HS-CRISPRi_LacZ)
By onHuman iPSCs were modified with CRISPRi to target LINE-1 retrotransposons, creating stable cell lines with different genetic backgrounds and guide RNAs. These resources are detailed in Adami et al. (DOI: 10.1016/j.xgen.2025.100979).
L1-silenced iPSC line (HS2_L1HS-CRISPRi_g1)
By onHuman iPSCs were modified with CRISPRi to target LINE-1 retrotransposons, creating stable cell lines with different genetic backgrounds and guide RNAs. These resources are detailed in Adami et al. (DOI: 10.1016/j.xgen.2025.100979).
