Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates
By onWe designed carbon fiber sensors that enable long-term simultaneous recording of both neurochemical and electrical neural activity in deep brain structures of nonhuman primates.
Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates
By onWe developed an implantable neural interface in monkeys that allows dual monitoring of electrical and chemical neural activity for long-term studies.
The human autophagy-initiating complexes ULK1C and PI3KC3-C1
By onULK1C and PI3KC3-C1 are crucial for macroautophagy initiation. Recent research focuses on their structural organization, activation mechanisms, and roles in autophagy initiation's protein interaction network for potential therapeutic targeting.
Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons
By onTo enable precise genetic targeting of key neuronal populations in the basal ganglia, we generated and characterized five knock-in mouse lines: Drd1-Cre, Adora2a-Cre, Drd1-FlpO, Adora2a-FlpO, and DAT-FlpO.
Autophagic stress activates distinct compensatory secretory pathways in neurons
By onNeurodegenerative diseases are linked to autophagy dysfunction causing harmful build-up of cellular waste. Neurons with Parkinson's mutation increase release of autophagic vesicles and exosomes, suggesting a protective response to chronic stress.
Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories
By onAuditory and temporal cortexes send strong excitatory signals to substantia nigra pars lateralis dopamine neurons, impacting threat conditioning. Inhibiting this pathway impairs memory retrieval, revealing its role in threatening behaviors.
Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum
By onDopaminergic neuron axons have GABAARs and nAChRs that influence DA release. GABAAR antagonism enhances nAChR activity, while picrotoxin inhibits nAChRs, revealing GABAARs' role in regulating nicotinic input onto DA axons.
Derailed degradation: LRRK2-dependent exocytosis in Parkinson’s disease
By onFerguson discusses new data on LRRK2 mutations increasing neuronal exocytosis of vesicles enriched in endosomal components. LRRK2 may promote lysosome exocytosis through interactions with GABARAP and Rab GTPases.
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
By onInherited mutations in VPS35 and LRRK2 cause Rab GTPase hyperphosphorylation. TMEM55B on lysosomes interacts with RILPL1 through a specific motif, forming complexes with various proteins, revealing new insights into lysosomal function.
Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
By onUsing single cell RNA sequencing, we demonstrate that LRRK2 G2019S is associated with an increased neutrophil presence in the colonic lamina propria during infection, Th17 skewing, upregulated Il17a, and greater colonic pathology.
LRRK2, lysosome damage, and Parkinson’s disease
By onRecent research has uncovered how LRRK2 kinase activity is regulated by recruitment to endolysosomal membranes, involving interactions with small GTPases and GABARAP. This sheds light on its role in lysosomal damage and Parkinson's disease.
Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities
By onThis perspective describes the vision and progress of the Global Parkinson's Genetics Program toward a more genetically representative understanding of Parkinson's disease.
