Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
By onNanoflow-based nMOST workflow quantifies proteins and lipids in LSD mutants, revealing autophagy defects and mitochondrial abnormalities in NPC1/NPC2 mutants.
α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice
By onThe study suggests that early circuit modulation could be an effective approach to alleviate symptoms associated with α-Syn pathology, necessitating studies of functional consequences of α-Syn aggregation.
Motor cortical circuit adaptations in parkinsonism
By onPerspective article on the publication (Chen et al. (2023), Sci Adv). It summarizes the major findings of this research paper and highlights a few potential future directions regarding the motor cortical circuit changes in parkinsonism.
Immune Senescence, Immunosenescence and Aging.
By onThis review focuses on age-related immune dysfunction, cellular senescence and the impaired immune response to pathogens.
Cellular Senescence: A Key Therapeutic Target in Aging and Diseases
By onThis paper discusses cellular senescence as a therapeutic target in aging and age-related diseases, as well as strategies and recent advances in the development of senotherapeutics targeting senescent cells to treat age-related diseases.
Genetically Encoded and Modular SubCellular Organelle Probes (GEM SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN
By onLysosomal and mitochondrial dysfunction are implicated in many diseases. GEM-SCOPe, a modular toolbox of fluorescent markers, helps visualize these organelles. In a PRKN-knockout model of PD, GEM-SCOPe identified disease-associated changes.
Development and characterization of a non-human primate model of disseminated synucleinopathy
By onThe intraputaminal delivery of AAV9-SynA53T resulted in a widespread synucleinopathy throughout the cerebral cortex and substantia nigra in the non-human primate brain.
Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: a comparative study with tranylcypromine
By onSafinamide (SAF) is used for PD by enhancing dopamine signal. SAF prolongs recovery from dopamine-mediated firing inhibition in SNpc DAergic neurons, mildly compared to tranylcypromine, suggesting multiple sites of action for SAF's therapeutics.
Cognitive dysfunction in animal models of human lewy-body dementia
By onSynucleinopathies like Parkinson’s Disease Dementia are linked to cognitive impairments due to Lewy bodies. Various methods, like genetic manipulation and toxin exposure, can model these pathologies in research to understand human diseases better.
Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport
By onRecent studies of VPS13 protein family reveal a novel intracellular lipid transport mechanism involving rod-like proteins forming a bridge with a hydrophobic groove for lipid transport, where their dysfunction may lead to disease.
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration
By onThe Endoplasmic Reticulum (ER) is crucial for cell function, interacting with other organelles through membrane contact sites. Mutations affecting ER proteins can lead to neurodegenerative diseases by disrupting lipid transport in cells.
Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content
By onUsing a reporter mouse line expressing tdTomato under control of DAT promoter in the gut and single cell sequencing we uncovered a novel population of DA neurons unique to the ENS which was ChAT/DAT-tdTomato-immunoreactive and expressed Grp, Calcb.
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery
By onDuring selective autophagy transmembrane cargo receptors can trigger autophagy by recruiting different complexes and utilizing multiple pathways. This flexibility in autophagy initiation has important therapeutic implications.
Movement-related activity in the internal globus pallidus of the parkinsonian macaque
By onThis study of MPTP-induced parkinsonism in macaques indicates that changes in the timing of task-related neural activity of the internal segment of the globus pallidus (GPi) correlate with the severity of motor impairments.
Induced Pluripotent Stem Cells: A Tool for Modelling Parkinson’s Disease
By onPD involves loss of dopaminergic neurons in the substantia nigra. Patient-derived iPSC models aid in understanding the disease and identifying potential treatments. More research is needed on age-related aspects and gene-environment interactions.
Prospects for Disease Slowing in Parkinson Disease
By onDespite advancements in understanding PD pathogenesis and developing targeted therapies, no treatment has proven effective in modifying the disease. This review discusses current pharmacological interventions in clinical trials for PD.
Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses
By onOur findings in this paper provide a unifying logic for how the developmental specification of diverse SNr neurons relates to the anatomical organization of basal ganglia circuits controlling specialized downstream brain regions.
Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson’s disease and Neurodegeneration with Brain Iron Accumulation disorders
By onDopamine, alpha-syn, and iron dysregulation contribute to vulnerability of substantia nigra dopaminergic neurons in Parkinson's and related disorders. Understanding their interplay is crucial for developing treatments to prevent disease progression.
Gut microbiome-mediated regulation of neuroinflammation
By onGut microbiome influences neuroinflammatory disease through pathways, including metabolite production, immune cell trafficking, and vagus nerve. Research on gut-brain axis has promising implications for understanding and treating neuroinflammation.
Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease
By onParkinson's disease affects both midbrain and enteric nervous system dopaminergic neurons. Shared factors and properties control their evolution, with potential for novel neurotrophic factors to be used as protection against PD symptoms in the ENS.
