Protocols

As part of the Aligning Science Across Parkinson’s (ASAP) initiative’s commitment to open science, it is important to us that ASAP-funded work can be leveraged by the research community. One way we ensure this is by making the experimental methods that comprise ASAP-funded work are replicable through protocol sharing.

Our Approach to Protocol Replicability

In an effort to improve the replicability of ASAP-funded research, we require all grantees to share a protocol or Methods paper for every Methods section in a manuscript. An assessment of protocol sharing in ASAP-funded publications showed that the policy’s implementation led to improved protocol sharing at the time of publication.

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ASAP Community on Protocols.io

ASAP grantees are encouraged to deposit their recipe-style protocols in a public repository. Since ASAP’s inception, over 1,800 protocols have been made publicly available through protocols.io, comprising over 5% of the protocols in this database. Engagement with these outputs is high, with some protocols ranked in the top 100 most-viewed on the site (over 6,000 views) and others actively receiving multiple bookmarks from users.

PPMI Study Design

The Parkinson’s Progression Markers Initiative (PPMI) is a landmark observational study dedicated to understanding Parkinson's disease. The PPMI Clinical protocol is designed to acquire comprehensive longitudinal within-participant data in approximately 4,000 participants enrolled at about 50 sites worldwide.

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Protocols in the ASAP Catalog

Our initiative is accelerating the pace of discovery for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. Browse our Catalog to view all ASAP-supported protocols.

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