From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson’s disease

By Patrick Lewis, PhD and Susanne Herbst, PhD
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Output Details

Description

Review of important new insights into LRRK2 structure and the complexes formed by this protein.

Identifier (DOI)
10.1042/BCJ20210383
Tags
  • LRRK2
  • Neurodegeneration
  • Parkinson's disease
Team
Team Hardy
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • Patrick Lewis, PhD

    Collaborating PI: Team Hardy, 

    Royal Veterinary College

  • Susanne Herbst, PhD

    Key Personnel: Team Hardy, 

    Royal Veterinary College

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Microscale thermophoresis is a powerful tool to measure the affinities of interactions between proteins. We present here our method for determining the binding of Rab29 GTPase to the LRRK2 N-terminal Armadillo domain.

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Aligning Science Across Parkinson's
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