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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Protocol
Immunohistochemistry Protocol – Chu Lab (Wichmann)
This protocol describes immunohistochemistry.
Teams
Article
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
Published: The authors developed a biophysically detailed multiscale model of mouse primary motor cortex (M1) with over 10,000 neurons and 30 million synapses. The model accurately predicted in vivo layer- and cell type-specific responses (firing rates and LFP) associated with behavioral states and experimental manipulations (noradrenaline receptor blocking and thalamus inactivation).
Teams
Teams
Protocol
Light microscopy immunoperoxidase staining
Protocol for Light microscopy immunoperoxidase staining.
Teams
Dataset
Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes (Dataset)
The data are interspike interval measurements generated from electrophysiological recordings of spontaneous spiking activities of single neurons in the basal ganglia of awake monkeys, before and after rendering them parkinsonian by treatment with MPTP. The animals were not engaged in any task or other structured activity.
Teams
Protocol
Perfusion-fixation procedure for adult rhesus monkeys
Perfusion-fixation procedure for adult rhesus monkeys.
Teams
Code
Mouse reaching task
This repository contains all the materials to build the mouse-reaching task and analyze the data acquired with this task.
Teams
Protocol
Standard operating procedure: Mouse stereotaxic intracranial injection surgery
The intent of this standard operating procedure (SOP) is to describe procedures for mouse stereotaxic intracranial injection surgery.
Teams
Protocol
Standard operating procedure: Mouse transcardiac perfusion protocol
Mouse transcardiac perfusion protocol and storage.
Teams
Code
twichma/Sequence-and-pattern-detection: Sequence and pattern detection code
Code for sequence and pattern analyses.
Teams
Article
Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
Published: The authors built a model of the primary sensory cortex (S1) in NetPyNE, using the data in the Neocortical Microcircuit Collaboration Portal. NetPyNE will make the S1 model more accessible and simpler to scale. View original preprint.
Teams
Article
Basal ganglia neurons in healthy and Parkinsonian primates generate recurring sequences of spikes
The authors conclude that basal ganglia neurons fire in recognizable sequences of ISIs, whose incidence is influenced by the induction of parkinsonism.
Teams
Article
Simulations predict differing phase responses to excitation vs. inhibition intheta-resonant pyramidal neurons
Published: The authors hypothesize that intrinsic cellular properties complement network properties and contribute to in vivo phase-shift phenomena such as phase precession, seen in place and grid cells, and phase roll, observed in hippocampal CA1 neurons. View original preprint.
Teams
Article
Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism
Preprint: The authors’ data suggest that cell subtype- and synapse-specific adaptations in M1 contribute to altered cortical outputs in parkinsonism and are important aspects of PD pathophysiology.
Teams