ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
The authors conclude that basal ganglia neurons fire in recognizable sequences of ISIs, whose incidence is influenced by the induction of parkinsonism.
Standard operating procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates
This protocol details standard operating procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates.
Viral Vector: Two rhesus macaque animals were tested for AAVrg-hSyn-mCherry in the spinal cord. The authors observed abundant mCherry-positive neurons in expected targets (i.e., motor cortical regions known to project to the spinal cord).
Published: The authors built a model of the primary sensory cortex (S1) in NetPyNE, using the data in the Neocortical Microcircuit Collaboration Portal. NetPyNE will make the S1 model more accessible and simpler to scale. View original preprint.
Perfusion-fixation procedure for adult rhesus monkeys.
The intent of this standard operating procedure (SOP) is to describe procedures for mouse stereotaxic intracranial injection surgery.
Mouse transcardiac perfusion protocol and storage.
Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes (Dataset)
The data are interspike interval measurements generated from electrophysiological recordings of spontaneous spiking activities of single neurons in the basal ganglia of awake monkeys, before and after rendering them parkinsonian by treatment with MPTP. The animals were not engaged in any task or other structured activity.
Code for sequence and pattern analyses.