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Output Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

  results for "Team Wichmann"
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Collection of protocols of Team Deleidi used in the publication: “”LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease””

Collection of protocols of Team Deleidi used in the publication: ""LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease""

Program: Collaborative Research Network
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Available ASAP-related hPSC collection from Team Studer

Collection of human pluripotent stem cell lines consisting of isogenic GBA, LRRK2, SNCA series, KI-reporter lines for TOMM20, b-actin, LAMB1, LAMP1, a-synuclein overexpression lines, and other hPSC resources.

Program: Collaborative Research Network
Team:
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Collection of protocols for paper: “Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function”

This is a collection of protocols used in a recent preprint by the Deleidi Lab, Team Schapira. You can access pre-print at https://doi.org/10.21203/rs.3.rs-1521848/v1

Program: Collaborative Research Network
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Multi-ancestry genome-wide meta-analysis in Parkinson’s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, all studies have been performed in just one population at the time. Here we performed the first large-scale…

Program: Global Parkinson's Genetics Program
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Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson’s disease

Objective This study aims to address disparities in risk prediction by evaluating the performance of polygenic risk score (PRS) models using the 90 risk variants across 78 independent loci previously linked to Parkinson’s disease (PD) risk across…

Program: Global Parkinson's Genetics Program
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Human Postmortem-Derived Brain Sequencing Collection (Harmonized Collection)

The Human Postmortem-derived Brain Sequencing Collection is a harmonized repository comprised of sequencing data contributed by ASAP CRN teams.

Program: Collaborative Research Network
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Standard Operating Procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates

This protocol details standard operating procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates.

Program: Collaborative Research Network
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MICROENDOSCOPIC CALCIUM IMAGING IN SUPPLEMENTARY MOTOR AREA AND PRIMARY MOTOR CORTEX OF RHESUS MACAQUES AT REST AND DURING ARM MOVEMENT

Motor cortical regions have undergone evolutionary expansion and specialization from rodents to primates. Studying these regions in non-human primates (NHPs) is relevant to understanding motor control in NHP models of movement disorders.

Program: Collaborative Research Network
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Non-human Primate Arm-reaching Behavioral Tasks

Protocol for training and testing non-human primates in arm-reaching tasks to evaluate parkinsonian animals

Program: Collaborative Research Network
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Miniscope calcium imaging data acquisition of cortical activity in non-human primates (NHPs)

The protocol describes head-mounted miniscope calcium imaging data acquisition for NHPs.

Program: Collaborative Research Network
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Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes

Data consists of interspike intervals from basal ganglia neurons in awake monkeys, pre- and post-parkinsonian treatment with MPTP. Recordings were during spontaneous spiking, without task involvement.

Program: Collaborative Research Network
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twichma/Sequence-and-pattern-detection: Sequence and pattern detection code

The code provided is for analyzing sequences and patterns.

Program: Collaborative Research Network
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Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes

Basal ganglia neurons fire in recognizable, repeating sequences of interspike intervals (ISIs), the incidence of which is influenced by the induction of Parkinsonism.

Program: Collaborative Research Network
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Dysfunction of Motor Cortices in Parkinson’s disease

In this review, the authors discuss PD-related changes in frontal cortical motor regions, focusing on neuropathology, changes in neurotransmission, and altered network interactions.

Program: Collaborative Research Network
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Rating scale for parkinsonian motor signs in macaques and other non‐human primates

This protocol details rating scale for Parkinsonian motor signs in macaques and other non‐human primates.

Program: Collaborative Research Network
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