2025: A Year in Review
We are proud to share how we impacted the Parkinson’s disease research field in 2025. Read our report to see how the infrastructure and processes we established are changing the way science is done and are generating significant momentum.
Bolen CosMx human Colon RNA and Protein code
By onRepository for the paper "Spatial single-cell multiomics..." includes CosMx assays, README files with scripts/data for analysis, and computational environment requirements. It also features a tissue microarray image showing morphology markers.
Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neurons
By onWe describe a multiomic-guided strategy that enriches SOX6+ mDA neurons by combining enhancing Sonic Hedgehog agonism with prolonged Wnt activation. This work is a reproducible differentiation platform for generating the PD-susceptible mDA subtype
Tansey Stool Meso Scale Discovery
By onStool samples of healthy controls and individuals with either PD or IBD analyzed for chemokines, cytokines, and ferritin levels using U-PLEX and R-PLEX assays on Quickplex MSD instrument.
Bolen Human Sigmoid Colon Protein CosMx Datasets
By onProtein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
Tansey Plasma Meso Scale Discovery
By onPlasma samples from individuals with Parkinson's disease, inflammatory bowel disease, or healthy controls were analyzed to measure chemokines and cytokines. The study used Quickplex MSD instrument following manufacturer's protocol.
Bolen Human Sigmoid Colon RNA CosMx Dataset
By onNanoString CosMx RNA dataset from human sigmoid colon of healthy controls, Parkinson's Disease, or inflammatory bowel disease exported for analysis.
Striatal ensembles specify and control granular forelimb actions
By onThe striatum plays a crucial role in controlling movements and learning. These results reveal specific ensembles of both D1- and D2-MSNs causally control specific ongoing actions, as granular as different muscle co-contractions of the same forelimb.
GRIN lens implant (1 mm) Protocol
By onThis is the standard 1 mm GRIN lens implant protocol for Rodrigues-Vaz and Athalye et al, 2025.
EMG recordings-Rodrigues-Vaz and Athalye et al, 2025
By onThis is the standard protocol for recordings of bulk EMG used for Rodrigues-Vaz and Athalye et al, 2025.
Perfusion and Histology Rodrigues-Vaz and Athalye et al, 2025
By onThis is the standard protocol for perfusion and histology of brain slices for Rodrigues-Vaz and Athalye et al, 2025.
Isometric forelimb task behavioral training
By onThis task is a self-paced task in which mice are reinforced for using their forelimb to apply force to an immobile joystick exceeding a threshold of duration and force.
Holographic calibration
By onThis is the standard protocol for 2-photon holographic calibration with In vivo Ultima Bruker microscope through GRIN lens used for Rodrigues-Vaz and Athalye et al, 2025.
Imaging using 2-photon microscope through GRIN lens
By onThis is the standard protocol for 2-photon imaging with Bruker microscope through GRIN lens used for Rodrigues-Vaz and Athalye et al, 2025.
Matters arising: Forced Symmetry Artifacts in a Prohibitin Complex Structure
By onLange et al. proposed a model for mitochondrial prohibitin complex with unequal subunit stoichiometry. Data suggests an asymmetric structure, questioning the validity of the proposed model. Care is needed in symmetry imposition in cryo-ET.
