Swollen lysosomes grab Rabs for a CASM-free route to LRRK2 activation
By onThis is a brief report on "ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes".
Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation: Mathematical Model
By onPrion Network Model: Julia modeling code, paper-specific analysis scripts, and figure reproduction workflow for nonlinear alpha-synuclein spread .
Coordinated spatial organization of basal ganglia structures revealed by dopamine subtype projectome mapping
By onHere, we map the subtype-specific projections of DA subtypes across various target regions. These findings provide a refined framework for understanding basal ganglia function and dysfunction in PD.
NHP microscopy images- Dataset 1
By onSpatial distribution of molecular markers in the macaque subthalamic nucleus using fluorescent in situ hybridization
Tissue processing and sectioning — Oscar Moreno Ramos and Divya Raj
By onThis protocol describes mouse brain fixation, sucrose cryoprotection, freezing, and sectioning before immunofluorescence on free-floating sections
NHP microscopy images- Dataset 2
By onQuantification of cell numbers in adult macaque brain sections with FISH labelling of brain tissue using different markers.
Human microscopy images
By onFISH labelling of brain tissue using different markers in adult human brain sections.
GolgiFold: A Structural Predictome of Human Golgi Protein Complexes
By onThis paper reports a structural interactome for the Golgi apparatus.
snRNA-seq Sex Validation & Stratified Integration Pipeline
By onNextflow pipeline for snRNA-seq analysis that validates donor sex using XIST and chrY expression, removes mislabeled samples, performs quality control and ambient RNA correction, and integrates datasets using Harmony or scVI for Parkinson’s research.
Alphafold predictions for GolgiFold Protein-Protein Interactions
By onThis entry is all the pairwise Alphafold models in GolgiFold as a web viewer.
PD-RISK Index: Piloting an unsupervised toolkit to identify adults with Parkinson disease
By onWe have successfully validated a simplified tool to detect Parkinson's for screening and diagnostic purposes. The PD-RISK toolkit comprises a self-reported 11-item questionnaire, an 8-scent smell test and an integrated score termed the PD-RISK Index.
Code used in article: PD-RISK Index: Piloting an unsupervised toolkit to identify adults with Parkinson disease
By onWe have successfully validated a simplified tool to detect Parkinson's for screening and diagnostic purposes. The PD-RISK toolkit comprises a self-reported 11-item questionnaire, an 8-scent smell test and an integrated score termed the PD-RISK Index.
An astrocytic AMPAR-dependent parity signal preserves synaptic strength
By onUsing AstroHTP, we blocked astrocytic AMPARs and found that ongoing glutamate activity triggers strong postsynaptic LTD, suggesting astrocytes act as a parity signal that stabilizes active synapses.
Human Wild-type alpha-synuclein protein expression and purification ASAP Modified
By onThe protocol is designed for high-yield purification of human recombinant α-synuclein monomer.
Mouse Striatal Astrocytes culture
By onThis protocol describes how to obtain striatal astrocyte cultures from postnatal mice (P0-P3).
Raw Data: Western Blot Images of PARK7 Protein Expression in Genetically Engineered Human iPSC Lines
By onWestern blot images comparing PARK7 protein expression in KOLF2.1J versus gene-edited PARK7 knockout, Park7 C-Terminal HaloTag, and Park7 SNV lines.
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
By onThis study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
FISH CODETECTION
By onDIG and Fluorescein labeled riboprobes Fluorescent in situ hybridization Frozen brain sections
