Calbindin KD Mouse – Experimental Cross

By Katherine Brimblecombe, PhD and Stephanie Cragg, PhD
View Published Lab Material

Output Details

Description
Calbindin-knockdown (CalbKD) animals were generated by crossing homozygous DAT IRES cre (RRID:IMSR_JAX:006660) mice with homozygous CalbTM2 mice (loxP sites flanking Exon1) donated by Prof. Meyer (University of Munich) (RRID:IMSR_JAX:031936), generating double-heterozygous offspring with decreased calb1 expression in DAT-expressing cells. CalbWT control mice were age- and sex-matched heterozygous DAT IRES cre mice. These experimental and control mice are not routinely maintained as a colony.
Tags
  • Mouse
Team
Team Cragg
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

Related Research

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s

This data show that LTCC function in DA axons, and isradipine effect, are locally governed and suggest they vary in a manner that in turn might impact on, or reflect, the cellular stress that leads to parkinsonian degeneration.

View Article

Dynamic basal ganglia output signals license and suppress forelimb movements-Datasets

This repository contains the datasets and analysis files associated with the study by Falasconi, Kanodia, and Arber (2025).

View Dataset

Supporting data for “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”

Data associated with “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”

View Dataset
View More Outputs