Citrobacter rodentium Model of Enteropathogenic and Enterohemorrhagic (EPEC, EHEC) Escherichia coli Infection

*[Citrobacter rodentium](https://www.google.com/search?q=Citrobacter+rodentium&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAB)* is a natural mouse pathogen widely used as a gold standard, in vivo, model to study human enteropathogenic (*[EPEC](https://www.google.com/search?q=EPEC&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAD)*) and enterohemorrhagic (*[EHEC](https://www.google.com/search?q=EHEC&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAE)*) *Escherichia coli* infections. It induces similar [attaching and effacing (A/E) lesions](https://www.google.com/search?q=attaching+and+effacing+%28A%2FE%29+lesions&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAF), [colitis](https://www.google.com/search?q=colitis&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAG), and [mucosal immune responses](https://www.google.com/search?q=mucosal+immune+responses&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAH) in mice, utilizing a similar [type III secretion system](https://www.google.com/search?q=type+III+secretion+system&oq=Citrobacter+rodentium+Model+of+Enteropathogenic+and+Enterohemorrhagic+%28EPEC%2C+EHEC%29+Escherichia+coli+Infection&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIGCAEQRRg8MgYIAhBFGD0yBggDEEUYPNIBBzM3NWowajeoAgCwAgA&sourceid=chrome&ie=UTF-8&ved=2ahUKEwiMysvFnuaSAxVsElkFHaenKSYQgK4QegQIARAI) (T3SS) to manipulate host cells. It is used to investigate mucosal immunity, inflammatory responses, and for testing treatments against A/E pathogens