Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes - Aligning Science Across Parkinson's

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Description

Pre-print link: https://www.biorxiv.org/content/10.1101/2022.11.14.516471v1 Pre-print DOI: 10.1101/2022.11.14.516471

Identifier (DOI)

10.1016/j.celrep.2023.112448

Tags

Autophagy
Axonal transport
iNeurons (induced neurons)
LRRK2
Original Research
PPM1H phosphatase

Team

Team Hurley

Program

Collaborative Research Network

Theme

PD Functional Genomics

Meet the Authors

Dan Dou

Key Personnel: Team Hurley,

University of Pennsylvania
Erin M. Smith

External Collaborator
Chantell Evans

External Collaborator
C Alexander Boecker

External Collaborator
Erika Holzbaur, PhD

Co-PI (Core Leadership): Team Hurley,

University of Pennsylvania