Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains
Published October 30, 2024
Output Details
Preprint June 21, 2022
Published October 30, 2024
Description
We provide an extensive single cell analysis profiling nearly 80,000 brain nuclei from prefrontal cortex of late-stage Parkinson’s disease brains, demonstrate that α-synuclein pathology is inversely correlated with chaperone expression in excitatory neurons, found a selective abatement of neuron-astrocyte interactions with enhanced neuroinflammation, and augmented the study with proteomic analysis and cross-comparisons with Alzheimer’s disease datasets, providing valuable insights into the pathways of neurodegeneration and a deep definition of the underlying molecular pathology for Parkinson’s disease.
Identifier (DOI)
10.1126/scitranslmed.abo1997
