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Tomogram of aggregate in AgDD-sfGFP-expressing HEK293 cell 10 min post aggregation induction

By Kelsey Hickey, PhD, Tillman Schaefer, Wolfgang Baumeister, Ruben Fernandez-Busnadiego, PhD, J. Wade Harper
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Output Details

Description
The aggregation of the artificial protein AgDD can be temporarily controlled to study its cellular effects. This output consists of a cryo-electron tomogram of an aggregate formed by AgDD in a HEK293 cell 10 min after inducing aggregation.
Tags
  • Cryo-ET
  • Human
  • In Cellulo
  • Microscopy - electron
  • Protein aggregates
Team
Team Harper
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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Tomogram of aggregate in AgDD-sfGFP-expressing HEK293 cell 6 h post aggregation induction

AgDD protein aggregation in HEK293 cells can be temporally controlled for studying cellular effects. A cryo-electron tomogram shows AgDD aggregate formation 6h post-induction.

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Aligning Science Across Parkinson's
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