Mutations in ATP13A2 gene can cause familial Parkinson's disease. Deleting ATP13A2 in adult mice leads to dopaminergic nerve terminal loss and neuronal degeneration, mimicking symptoms of ATP13A2-related neurodegenerative diseases.
Protein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
New micro-fiber array allows chronic measurement and optogenetic manipulation at 100+ locations in mice, for studying cell-type and neurotransmitter-specific signals in 3-D volumes. Protocol involves micro-CT scanning and fiber localization.
