A prebiotic diet modulates microglia response and motor deficits in α-synuclein overexpressing mice (Dataset)
By savannah onThese studies uncover a novel microglia-dependent interaction between diet and motor symptoms in mice, findings that may have implications for neuroinflammation and PD.
The mass spectrometry proteomics data associated of TauRD-Y interactome from TauRD-Y and TauRD-Y* cells
By savannah onThe mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE84 partner repository with the dataset identifier PXD023400. Associated with the following preprint: Saha et al., 2022 (published on biorxiv on February 19, 2022). https://www.biorxiv.org/content/10.1101/2022.02.18.481043v1.full
Structure of wild-type PPM1H phosphatase at 3.1 Angstrom resolution
By savannah onStructure of wild-type PPM1H phosphatase at 3.1 Angstrom resolution (as reported in 10.15252/embr.202152675) deposited in the Protein Data Bank with code 7KPR.
Structure of PPM1H phosphatase with manganese ions at the active site
By savannah onStructure of PPM1H phosphatase with manganese ions at the active site (as reported in 10.15252/embr.202152675) deposited in the Protein Data Bank with code 7N0Z.
Crystal structure of a substrate-trapping variant of PPM1H phosphatase
By savannah onCrystal structure of a substrate-trapping variant of PPM1H phosphatase (as reported in 10.15252/embr.202152675) deposited in the Protein Data Bank with code 7L4I.
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
By savannah onExperimental Data Snapshot Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer PDB DOI: 10.2210/pdb8DO8/pdb Classification: SIGNALING PROTEIN Organism(s): Homo sapiens Expression System: Homo sapiens Mutation(s): No Deposited: 2022-07-12 Released: 2022-11-23 Deposition Author(s): Buffalo, C.Z., Ren, X., Yokom, A.L., Hurley, J.H. Funding Organization(s): Other private Method: X-RAY DIFFRACTION Resolution: 2.41 Å R-Value Free: 0.251 R-Value Work: 0.204 R-Value Observed: 0.205
Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures – Gene Validation FCS
By savannah onFCS files corresponding to the gene validation experiment described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures."
Axonal and somatodendritic proteomes of dopamine neurons in the mouse brain
By savannah onThe elaborate cytoarchitecture of DA neurons is embedded within complex brain tissues, making it difficult to access the DA neuronal proteome using conventional methods. This mass spectrometry proteomics dataset is a part of "Subcellular proteomics of dopamine neurons in the mouse brain" (Hobson et al., 2022).
Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures – Cell Surface FCS
By savannah onFCS files corresponding to the cell surface experiment described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures."
Primary data associated with the manuscript “Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content” (doi.org/10.1101/2022.11.22.517583)
By savannah onRaw data files used for the manuscript "Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content" (doi.org/10.1101/2022.11.22.517583).
Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures – Fluorospot SFC
By savannah onFluorospot SFC (combined IFNg, IL-5, and IL-10) data and corresponding HC-PD group IDs described in "Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures."
ENS quantification
By savannah onLabelled enteric neurons in living mice with recombinant adeno-associated viruses (rAAVs) expressing fluorescent proteins, and used tissue clearing techniques to enhance visualization of intact GI tissue.
Subcellular and regional localization of mRNA translation in midbrain dopamine neurons
By savannah onThis dataset is a part of "Subcellular and regional localization of mRNA translation in midbrain dopamine neurons" (Hobson et al., 2022) where the authors investigated mRNA localization in midbrain dopaminergic (mDA) neurons, cells with enormous axonal and dendritic projections, both of which can release dopamine (DA).
A single-cell atlas of cell types, states, and other transcriptional patterns from nine regions of the adult mouse brain
By savannah onWe report 690K single-cell transcriptomes from nine different brain regions from adult mice (Frontal and Posterior Cortex, Hippocampus, Thalamus, Cerebellum, Striatum, Globus Pallidus externus/Nucleus Basalis, Entopeduncular / Subthalamic Nuclei, & Substantia Nigra / Ventral Tegmental Area).
Peripheral neuronal activation of the intestinal tract shapes the microbiome and alters gut physiology-RNAseq
By savannah onThis RNA data set corresponds to the preprint: Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice (Yoo et al., 2021).
Primary data associated with doi: 10.7554/eLife.67900 (Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain)
By quincy.tichenor onImmunofluorescence microscopy images, raw immunoblotting data and tabular data used to generate graphs shown in all figures.
Primary data associated with doi: 10.15252/embr.202152675 (Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO Rep. 2021 Nov 4;22(11):e52675)
By quincy.tichenor onRaw immunoblotting data; Scans of Coomassie-stained SDS-PAGE gels; Tabular data for quantifications; List of cross-links with distances; Numerical data for in vitro assays; Data files from Astra Software analysis.
Mass spectrometry proteomic data supporting the PPM1H/Rab8A crosslinking study described in doi: 10.15252/embr.202152675
By quincy.tichenor onMass spectrometry proteomic data supporting the PPM1H/Rab8A crosslinking study described in doi: 10.15252/embr.202152675, deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD026367
Primary data associated with Figure 3–Figure Supplement 4 in doi: 10.1101/2022.04.25.489459
By quincy.tichenor onRaw immunoblotting data and tabular data for quantitation used to generate Figure 3–Figure Supplement 4 in doi: 10.1101/2022.04.25.489459 ("A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation").
Primary data associated with doi: 10.1101/2022.04.25.489459 (A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Apparent Activation)
By quincy.tichenor onRaw immunoblotting data; tabular data for quantifications; immunofluorescence images.
