MS proteomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
By Emma Sherrell onMS proteomics data related to "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease" deposited to the MassIVE repository with the dataset identifier MSV000090202.
Metabolomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
By Emma Sherrell onThe metabolomics is submitted at the NIH Common Fund’s National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org where it has been assigned Project ID (PR001491). The data can be accessed directly via its Project DOI: (https://doi.org/10.21228/M80M7R).
Figure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity [FINAL]
By savannah onFigure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity.
Figure 7. Pacer expression promotes formation of WIPI2 puncta upon depolarization [FINAL]
By Emma Sherrell onFigure 7. Pacer expression promotes formation of WIPI2 puncta upon depolarization.
Figure 6: Pacer LC3B imaging [FINAL]
By Emma Sherrell onFigure 6. pRAB7A-dependent function of Pacer in mitophagosome expansion.
Figure 5: Pacer Flux [FINAL]
By Emma Sherrell onFigure 5. Pacer is a pS72 RAB7A-dependent activator of mitophagy.
Figure 4: The Pacer RH domain basic triad controls subcellular localization [FINAL]
By Emma Sherrell onFigure 4. The Pacer RH domain basic triad controls subcellular localization.
Figure 3: Rubicon – Rab7 binding colocalization [FINAL] Creators
By Emma Sherrell onFigure 3. pRAB7A binding preferences dictate subcellular localization.
Figure 1: Rubicon KO starvation and mitophagy HaloTag processing assay
By Emma Sherrell onFigure 1. Rubicon depletion promotes bulk autophagy and Parkin mitophagy.
Figure S2. pS72 Rab7 formation following depolarization, starvation, and iron chelation [FINAL]
By Emma Sherrell onFigure S2. pS72 Rab7 formation following depolarization, starvation, and iron chelation.
Figure S4: MW weight of gels [FINAL]
By Emma Sherrell onFigure S4. MW verification of HaloTag flux reporters.
Figure S3: Immunofluorescence of mitochondria alongside LC3B [FINAL]
By Emma Sherrell onFigure S3. Immunofluorescence of mitochondria alongside LC3B.
Reach-related single unit activity in the Parkinsonian macaque
By Emma Sherrell onThis dataset contains recordings of single-unit activity from multiple brain areas, including globus pallidus-internus (GPi), ventrolateral nucleus of the thalamus (VLa and VLp), and the arm-related regions of the primary motor cortex, including sulcus (M1-S) and gyrus (M1-G) subregions, in monkeys performing a choice reaction time reaching task.
Erb et al 2024 datasets
By savannah onDatasets for Erb et al 2024 "Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities."
Image distortion data from “An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys”
By savannah onImage distortion data associated with the manuscript "An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys."
EMG data from “An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys”
By savannah onEMG data from the manuscript, "An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys."
IHC data of TYROBP from Kilfeather, P. et al., 2024
By savannah onRaw microscopy images and quantification of TYROBP expression.
IHC data and analysis of CASR in Kilfeather et al., 2023
By savannah onRaw microscopic images and quantification of CASR expression.