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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
Experimental Data Snapshot
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
PDB DOI: 10.2210/pdb8DO8/pdb
Classification: SIGNALING PROTEIN
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2022-07-12 Released: 2022-11-23
Deposition Author(s): Buffalo, C.Z., Ren, X., Yokom, A.L., Hurley, J.H.
Funding Organization(s): Other private
Method: X-RAY DIFFRACTION
Resolution: 2.41 Å
R-Value Free: 0.251
R-Value Work: 0.204
R-Value Observed: 0.205
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Dataset
Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-04
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Dataset
Structure of human ULK1C:PI3KC3-C1 supercomplex
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-05
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Dataset
Structure of human PI3KC3-C1 complex
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-04-29
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Dataset
Structure of human ULK1 complex core (2:1:1 stoichiometry)
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-04-28
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Dataset
Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-05
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Article
In situ structural analysis reveals membrane shape transitions during autophagosome formation
Preprint: A hallmark of PD is the failure of quality control mechanisms in the cell, such as autophagy. The authors combined cell biology with correlative cryo-electron tomography in yeast cells to show a high resolution stepwise structural progression of autophagosome biogenesis. Further, they revealed the organelle interactome for growing autophagosomes.
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Lab Resource
pCAG-TSF-ATG13 (450-517)-ULK1 (836-1050)
Mammalian expression of ATG13 C-terminal and ULK1 MIT domain fusion complex.
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