New Imaging Tech Spots Hidden Protein Predicting Parkinson’s Disease
This news story reports on a new, advanced imaging method that allowed CRN Team Wood to see and study the tiny, toxic alpha-synuclein oligomers (protein clumps) in the brain, creating a new opportunity for earlier diagnosis and better drug treatments.
Immunofluorescence source data
By onThese files include the raw, unedited, immunofluorescence images.
Western blot source data
By onSource Data for Western Blots in Main Figures 1-7 and Supplemental Figures 1, 3-5
Original data for Figures 1-7 & Figure EV1-EV4A [Hanna et al. 2024]
By onOriginal data for Figures 1-7 & Figure EV1-EV4A from Hanna et al 2024
SIFT based MATLAB script [Hanna et al 2024]
By onSIFT based MATLAB script used in the preprint Hanna et al 2024
Python code: Figure generating script [Hanna et al 2024]
By onPython code: Figure generating script used in the preprint Hanna et al 2024
ImageJ code: Analysis script_0 [Hanna et al 2024]
By onImageJ code: Analysis script_0 used in the preprint Hanna et al 2024
Script for image quantification [Wang et al 2025]
By onScript for image quantification used in Wang et al 2025
Release Notes – ASAP CRN Cloud
By onSummary: Release notes for version 1.0.0 of CRN Cloud platform, released on June 25, 2024, detailing latest updates and enhancements.
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
By onLysosomal Storage Disorders impact lysosomal function and can be linked to Parkinson's Disease risk. LSD mutant cells show varied endolysosomal proteomes, with specific disruptions in neuronal cells.
Leucine Rich Repeat Kinase 2: Pathways to Parkinson’s Disease
By onResearch on LRRK2 in Parkinson's disease has advanced, revealing how mutations activate the kinase, phosphorylate Rab proteins, disrupt cell functions like Hedgehog signaling, and contribute to the disease. LRRK2 inhibitors show promise for therapy.
Flow cytometry data related to ‘The lipid flippase ATP10B enables cellular lipid uptake under stress conditions’
By onFlow cytometry data related to 'The lipid flippase ATP10B enables cellular lipid uptake under stress conditions'
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
By onCryo-ET showed protein aggregates, altered cristae, and reduced ribosome complexes in stressed mitochondria. Mitochondrial Hsp60 undergoes conformational changes to aid in protein folding, shedding light on mitochondrial proteostasis mechanisms.
Lipid dynamics at membrane contact sites
By onLipid building blocks in eukaryotes are mainly produced in the endoplasmic reticulum and moved to other organelles via vesicles or proteins at organelle contact sites. We review what is known.
Quantification of Axonal Projections from Whole-Brain Slide Images
By onQuantification of Axonal Projections from Whole-Brain Slide Images provides a standardized method for processing and analyzing immunofluorescence images of mouse brain sections to quantify axonal projections.
IBA1 Immunochemistry on human paraffin sections
By onIba1-specific Immunochemistry protocol on paraffin-embedded human brain sections
Olympus Slideview VS200″ slide scanning
By onBrief guide on the main steps to follow in order to scann a sample with the "Olympus Slideview VS200 slide scanner. Although examples for certain parameters are presented, each user should choose them based on the characteristics of their samples.
