PINK1 WT/LRRK2 WT, PINK1 WT/LRRK2 RC, PINK1 KO/LRRK2 WT, PINK1 KO/LRRK2 RC
By onMice with LRRK2 R1441C and PINK1 KO mutations were crossed to create double mutant lines: LRRK2 WT/PINK1 WT, LRRK2 RC/PINK1 WT, LRRK2 WT/PINK1 KO, and LRRK2 RC/PINK1 KO.
Lrrk2 flox-R1441G
By onDardarin/Lrrk2 regulates inflammation, protein processing, and autophagy. Mutations, like R1441G, linked to Parkinson's disease. LRRK2 flox-R1441G mice model the disease for research, showing normal phenotype until gene manipulation.
Drd1-T2A-Cre mouse line
By onDopamine D1 receptor cre knock in mouse line generated by the Costa lab.
Anxa1-P2A-Cre Mouse line
By onAnxa1-Cre knock-in mice express cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Slc6a3-T2A-FlpO (DAT-flpO) Mouse Line
By onDAT-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Slc6a3 (DAT) promoter in Slc6a3-expressing cells, including dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Adora2a-T2A-FlpO Mouse Line
By onAdora2a-Cre line generated by Cyagen for the Costa lab crossed with a FlpO line.
Drd1-T2A-FlpO Mouse Line
By onDopamine D1 receptor FlpO mouse line generated by the Costa lab at Cyagen using CRISPR/Cas-mediated genome engineering.
Adora2a-T2A-Cre Mouse Line
By onAdora2a-Cre line generated by Cyagen using CRISPR/Cas-mediated genome engineering for the Costa lab.
Calbindin KD Mouse – Experimental Cross
By onTransgenic mouse model with decreased calb1 expression in DAT-expressing cells.
