Datasets and Key Resources Table used in Do, Quyen B. et al. (2023) “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation”
By onThe files found here are associated to Do, Q. et al (2023) study and contain: (a) all source and supplementary data, (b) Key Resources Table, and (c) list of primers.
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
By onThe authors developed a multiscale model of mouse primary motor cortex with over 10,000 neurons and 30 million synapses. The model accurately predicted cell type-specific responses associated with behavioral states and experimental manipulations
EPSCs source data across different simulation intensities of thalamus PT, IT neurons, and SC PT neurons
By onSource data compares EPSCs in thalamus PT, IT neurons, and SC PT neurons between control and 6_OHD mice across varying simulation intensities.
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
By onData consists of interspike intervals from basal ganglia neurons in awake monkeys, pre- and post-parkinsonian treatment with MPTP. Recordings were during spontaneous spiking, without task involvement.
Tabular data of fast-scanning voltammetry and physiology experiments in LRRK2 KI mice
By onThe tabular data of fast-scanning cyclic voltammetry and physiology experiments from manuscript: "R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations." by Xenias et al.
Day2023 supplementary dataset
By onDatasets for all supplementary figures S1-4 in GABAergic regulation of striatal spiny projection neuron excitability depends upon their activity state (2023).
Source data for “Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons”
By onSource Data and images from the paper: Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons
Systemic inflammation triggers long-lasting neuroinflammation and accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human α-synuclein
By onPD involves genetic and environmental factors, inflammation potentially playing a key role. On rats LPS injection caused inflammation and dopaminergic neuronal loss in Snca+/+ rats, impacting dopamine release. Behavioral changes were not significant.
Intracellular neuromelanin from post-mortem human midbrain and pontine
By onThis data set includes different quantification parameters to identify the features of intracellular neuromelanin.
EMG data from “An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys”
By onEMG data from Liang et al. 2024 10.1016/j.jneumeth.2024.110133.
Reach-related Single Unit Activity in the Parkinsonian Macaque
By onThis dataset contains recordings of single-unit activity from multiple brain areas in monkeys performing a choice reaction time reaching task.
Reward perseveration is shaped by GABAA-mediated dopamine pauses: Electrophysiology Data
By onSummarized electrophysiology raw data grouped by animal and raw histological images, drawn ROIs and ilastik cell counting to compare TH and HTP expression
Source data for “α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease”
By onSource data and images for paper.
Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: a comparative study with tranylcypromine
By onSafinamide (SAF) is used for PD by enhancing dopamine signal. SAF prolongs recovery from dopamine-mediated firing inhibition in SNpc DAergic neurons, mildly compared to tranylcypromine, suggesting multiple sites of action for SAF's therapeutics.
Datasets, Code and Key Resources Table from Brimblecombe, K. et al (2023) “Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s”
By onThe following files are associated with Brimblecombe, K. et al (2023) study: (a) Key Resources Table, (b) all tabular datasets, and (c) Custom R code used to analyse all datasets.
Datasets and Key Resources Table used in Nebuloni, F. et al. (2024) “A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy”
By onThe files found here are associated to Nebuloni, F. et al (2024) study and contain: (a) all source and supplementary data and (b) Key Resources Table.
Data for outlier-waveform-detection of internal globus pallidus (GPi) activity
By onThis repository contains data based on neuronal recordings from two monkeys (G and I, in the pre- and post-MPTP states) that serve as input to the code provided at .
Datasets and Key Resources Table used in Stedehouder & Roberts (2024) “Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes”
By onThis repository contains a Key Resources Table with details on lab materials and the persistent identifiers for protocols and code used and generated in this study; and tabular datasets shown in main and supplementary figures.
