LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model
By onPD is a neurodegenerative disorder characterized by the loss of neuromelanin (NM)-containing dopamine neurons. This work highlights NM-activated microglia’s role in PD progression, and provides a model for testing therapeutic targets.
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease
By onNeuromelanin (NM) is pigment accumulating with age in human SNpc dopamine (DA) neurons. This study discloses unrealized NM effects within nigral DA neurons, advancing our comprehension of sex-specific features shaping sex-biased vulnerability to PD.
Dan Lab sleep datasets for MCI-Park mice 24-hour recordings
By onSleep-wake dataset for MCI-Park mice and wildtype controls from Dan Lab.
Source data for Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
By onChen et al (2024) study links α-synuclein aggregation to hyperexcitability in motor cortical neurons.
Source data for the article “α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice”
By onα-Synuclein aggregation in mice reduces cortico-amygdala connectivity, leading to impaired social behavior.
Datasets and Key Resources Table used in Do, Quyen B. et al. (2023) “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation”
By onThe files found here are associated to Do, Q. et al (2023) study and contain: (a) all source and supplementary data, (b) Key Resources Table, and (c) list of primers.
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
By onThe authors developed a multiscale model of mouse primary motor cortex with over 10,000 neurons and 30 million synapses. The model accurately predicted cell type-specific responses associated with behavioral states and experimental manipulations
EPSCs source data across different simulation intensities of thalamus PT, IT neurons, and SC PT neurons
By onSource data compares EPSCs in thalamus PT, IT neurons, and SC PT neurons between control and 6_OHD mice across varying simulation intensities.
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
By onData consists of interspike intervals from basal ganglia neurons in awake monkeys, pre- and post-parkinsonian treatment with MPTP. Recordings were during spontaneous spiking, without task involvement.
Tabular data of fast-scanning voltammetry and physiology experiments in LRRK2 KI mice
By onThe tabular data of fast-scanning cyclic voltammetry and physiology experiments from manuscript: "R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations." by Xenias et al.
Day2023 supplementary dataset
By onDatasets for all supplementary figures S1-4 in GABAergic regulation of striatal spiny projection neuron excitability depends upon their activity state (2023).
Source data for “Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons”
By onSource Data and images from the paper: Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons
Systemic inflammation triggers long-lasting neuroinflammation and accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human α-synuclein
By onPD involves genetic and environmental factors, inflammation potentially playing a key role. On rats LPS injection caused inflammation and dopaminergic neuronal loss in Snca+/+ rats, impacting dopamine release. Behavioral changes were not significant.
Intracellular neuromelanin from post-mortem human midbrain and pontine
By onThis data set includes different quantification parameters to identify the features of intracellular neuromelanin.
EMG data from “An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys”
By onEMG data from Liang et al. 2024 10.1016/j.jneumeth.2024.110133.
Reach-related Single Unit Activity in the Parkinsonian Macaque
By onThis dataset contains recordings of single-unit activity from multiple brain areas in monkeys performing a choice reaction time reaching task.
Reward perseveration is shaped by GABAA-mediated dopamine pauses: Electrophysiology Data
By onSummarized electrophysiology raw data grouped by animal and raw histological images, drawn ROIs and ilastik cell counting to compare TH and HTP expression
Source data for “α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease”
By onSource data and images for paper.
