Tansey Stool Meso Scale Discovery
By onStool samples of healthy controls and individuals with either PD or IBD analyzed for chemokines, cytokines, and ferritin levels using U-PLEX and R-PLEX assays on Quickplex MSD instrument.
Bolen Human Sigmoid Colon Protein CosMx Datasets
By onProtein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
Tansey Plasma Meso Scale Discovery
By onPlasma samples from individuals with Parkinson's disease, inflammatory bowel disease, or healthy controls were analyzed to measure chemokines and cytokines. The study used Quickplex MSD instrument following manufacturer's protocol.
Data for: Allosteric regulation of the Golgi-localized PPM1H phosphatse by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson’s disease LRRK2-counteracting PPM1H phosphatase
By onRaw tabular data and original TIFF files available for Western blots. Raw tabular data provided for all MST binding experiments.
Western blot source data
By onSource Data for Western Blots in Main Figures 1-7 and Supplemental Figures 1, 3-5
Mass spectrometry proteomics dataset
By onThe mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD053892
LRRK2 alters the composition and organization of active zone release sites in dopaminergic striatal synaptosomes
By onConfocal images and analysis overview
Proteomics for STING KO and STINGRRAA RAW 264.7 macrophages
By onUsing immunopeptidomics analysis we showed that STING regulates the repertoire of peptides displayed at the cell surface of macrophages during inflammation, highlighting a potential role in immunosurveillance and potential targets for therapy
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
By onOriginal gels with their repeats, associated with pre-print
Primary data associated with Figure 3–Figure Supplement 4 in doi: 10.1101/2022.04.25.489459
By onRaw immunoblotting data and tabular data for quantitation used to generate Figure 3–Figure Supplement 4 in doi: 10.1101/2022.04.25.489459 ("A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation").
Primary data associated with doi: 10.1042/BCJ20220161 (Impact of 100 LRRK2 variants linked to Parkinson’s Disease on kinase activity and microtubule binding)
By onRaw immunoblotting data; tabular data for quantifications; numerical data for in vitro assays; immunofluorescence images; Prism files for statistical analysis.
Crystal structure of a substrate-trapping variant of PPM1H phosphatase
By onCrystal structure of a substrate-trapping variant of PPM1H phosphatase (as reported in 10.15252/embr.202152675) deposited in the Protein Data Bank with code 7L4I.
Structure of wild-type PPM1H phosphatase at 3.1 Angstrom resolution
By onStructure of wild-type PPM1H phosphatase at 3.1 Angstrom resolution (as reported in 10.15252/embr.202152675) deposited in the Protein Data Bank with code 7KPR.
Primary data associated with the manuscript “Genome-wide screen reveals Rab12 GTPase as 2 a critical activator of Parkinson’s disease-linked LRRK2 kinase” (2/3)
By onPrimary data associated with the manuscript, "Genome-wide screen reveals Rab12 GTPase as 2 a critical activator of Parkinson’s disease-linked LRRK2 kinase."
Proteomic data reported in doi.org/10.1073/pnas.2219953120 (Golgi-IP, a tool for multimodal analysis of Golgi molecular content)
By onProteomic data associated with doi.org/10.1073/pnas.2219953120 deposited in ProteomeXchange PRIDE repository with PID: PXD038046.
Primary data associated with the manuscript “Genome wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase” (doi: 10.1101/2023.02.17.529028)
By onPrimary data associated with the manuscript "Genome wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase"
Primary data associated with the manuscript “Parkinson’s VPS35[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B” (doi: 10.1101/2023.06.07.544051)
By onConfocal microscopy images, CellProfiler Excel files of Pearson's coefficients between TMEM55B/RILPL1 or pRab10/RILPL1 in R1441C MEF or VPS35 MEF cells as seen in doi: 10.1101/2023.06.07.544051.
Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function
By onRaw data files used for the manuscript "Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function" https://www.researchsquare.com/article/rs-1521848/v1
Primary data associated with the manuscript “Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content” (doi.org/10.1101/2022.11.22.517583)
By onRaw data files used for the manuscript "Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content" (doi.org/10.1101/2022.11.22.517583).
