Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Program
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CRN Team Name
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Theme
Nestin-cre;Ercc1-/fl mice
Pan-neuronal cell types may experience higher levels of internal DNA damage and potential senescence due to various factors.
Th-cre;Ercc1-/fl mice
Dopaminergic neurons may experience elevated DNA damage and potential senescence, suggesting implications for neurodegenerative disorders.
Oligo2-cre;Ercc1-/fl mice
Oligodendrocytes may experience higher levels of DNA damage and potential senescence due to internal factors.
Cx3cr1-cre;Ercc1-/fl mice
Microglia may experience higher levels of DNA damage and potential senescence due to internal factors.
Dan Lab sleep datasets for MCI-Park mice 24-hour recordings
Sleep-wake dataset for MCI-Park mice and wildtype controls from Dan Lab.
pAAV-hsyn-DIO-Rpl22l1-3Flag-2A-eGFP-WPRE
Expression of a Flag-tagged Rpl22I1 protein in cells expressing Cre recombinase allowing for the harvesting of actively transcribed mRNAs in that cell type.
Drd1-T2A-Cre mouse line
Dopamine D1 receptor cre knock in mouse line generated by the Costa lab.
Anxa1-P2A-Cre Mouse line
Anxa1-Cre knock-in mice express cre recombinase from the mouse Anxa1 promoter in Anxa1-expressing cells and subtypes of dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Slc6a3-T2A-FlpO (DAT-flpO) Mouse Line
DAT-FlpO knock-in mice express optimized Flp recombinase (FlpO) from the mouse Slc6a3 (DAT) promoter in Slc6a3-expressing cells, including dopaminergic neurons. This strain is useful in studies of motor neuron deficits in Parkinson's disease.
Adora2a-T2A-FlpO Mouse Line
Adora2a-Cre line generated by Cyagen for the Costa lab crossed with a FlpO line.
Drd1-T2A-FlpO Mouse Line
Dopamine D1 receptor FlpO mouse line generated by the Costa lab at Cyagen using CRISPR/Cas-mediated genome engineering.
Adora2a-T2A-Cre Mouse Line
Adora2a-Cre line generated by Cyagen using CRISPR/Cas-mediated genome engineering for the Costa lab.
Ef1a-DIO-PSAML-141F,Y115F-GlyR-2A-FusionRed plasmid
Pharmacologically Selective Actuator Module, chimeric ligand-gated ion channels that can be used to manipulate electrophysiological activity.
RNA Seq dataset for: α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Actively transcribed messenger ribonucleic acids (mRNAs) were harvested from SNc dopaminergic neurons in aSYN monomer or PFF-injected mice 12 weeks post injection and then subjected to RNASeq analysis.
pAAV-Con/Fon-N2cG
This plasmid was generated by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201) for our study and injected to label presynaptic inputs to SNr neurons.
