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Output Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

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Plasmid construction – Chen et al. 2025 NSMB

Standard cloning procedure.

Program: Collaborative Research Network
Team:
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Image Processing and 3D Reconstruction – Chen et al. 2025 NSMB

Image processing and 3D reconstruction applied in Chen et al. 2025 NSMB

Program: Collaborative Research Network
Team:
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Mass photometry V.2

A protocol for performing mass photometry measurements.

Program: Collaborative Research Network
Team:
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EMD-40658

Structure of human ULK1 complex core (2:1:1 stoichiometry)

Program: Collaborative Research Network
Team:
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EMD-45297

Structure of human ULK1C:PI3KC3-C1 supercomplex

Program: Collaborative Research Network
Team:
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EMD-40715

Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture

Program: Collaborative Research Network
Team:
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EMD-40735

Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant

Program: Collaborative Research Network
Team:
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8SQZ

Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture

Program: Collaborative Research Network
Team:
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Protocols for Goldman et al. 2025

All protocols related to GEM-SCOPe and described in Glodman et al. 2025

Program: Collaborative Research Network
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all data related to “Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout”

Raw imaging data for "Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout"

Program: Collaborative Research Network
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Neuromelanin and selective neuronal vulnerability to Parkinson’s disease

Neuromelanine (NM), a pigment in human catecholamine neurons, plays a crucial role in PD. We review the development of NM in dopamine versus noradrenaline neurons and focus on previously overlooked cellular organelles in NM format and function.

Program: Collaborative Research Network
Team:
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Reply to: Is Gauchian genotyping of GBA1 variants reliable?

Summarizing a study by N. Tayebi et al. in Communications Biology, published in 2025.

Program: Collaborative Research Network
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Dynamic basal ganglia output signals license and suppress forelimb movements-Datasets

This repository contains the datasets and analysis files associated with the study by Falasconi, Kanodia, and Arber (2025).

Program: Collaborative Research Network
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End-product inhibition of the LRRK2-counteracting PPM1H phosphatase

PPM1H phosphatase reverses Rab GTPase phosphorylation by LRRK2 in Parkinson's disease. PPM1H binds Rab8A and Rab10 at an allosteric site, inhibiting phosphatase activity. Targeting this site may offer a therapeutic strategy.

Program: Collaborative Research Network
Team:
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Characterizing Parkinson’s Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder

a-syn SAA positivity, DaT positivity, and hyposmia are highly associated with each other. MDS Prodromal PD Probability scores may be useful predictors of near-term progression, and thus as a stratification factor in clinical research study design

Program: Collaborative Research Network
Team:
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