ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Synaptic Location Is a Determinant of the Detrimental Effects of alpha-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Publication: α-Synuclein in mouse brain is not ubiquitously expressed among glutamatergic axon terminals in the basolateral amygdala (BLA). This work looks at the distinctive characteristics between neuronal subtypes to understand which ar emore vulnerable to α-Synuclein aggregation and how this in turn could impact the entire circuit signaling. View the original preprint.
Preprint: The authors develop a novel approach for deriving the time-varying functional connectivity of cortical networks and show this information encodes rapid fluctuations in behavioral state.