Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

Article

Vesicular dysfunction and pathways to neurodegeneration

This review summarizes vesicle trafficking and neurodegeneration by focusing on critical pathways for neuronal survival in the brain.

Article

From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson’s disease

This review summarizes LRRK2 structure both in a historical and current context, highlighting new insights into the structure of LRRK2 and complexes it forms.

Article

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias

Hereditary Spastic Paraplegias are a group of neurodegenerative disorders with diverse clinical presentation and genetic variability. The authors used validated human data to create a protein-protein interaction map using causative genes to identify core proteins and processes. They find further classification can be performed based on specific molecular mechanisms. View preprint.

Article

In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung

LRRK2 mutations are the most frequent cause of familial Parkinson’s disease. But LRRK2 is expressed in numerous tissues aside from the brain warranting a deeper computational analysis of LRRK2 direct interactors across different tissues. The authors found specific targets for the tissues studied, namely brain, kidney, and lungs.