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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Protocol
RNA and protein extraction from bulk dissections
Protocol for RNA and protein extraction from bulk dissections.
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Protocol
Stereotaxic rat brain surgery for Substantia Nigra targeting
Protocol for stereotaxic rat brain surgery for Substantia Nigra targeting.
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Protocol
Gene expression analysis by qPCR
Protocol for gene expression analysis by quantitative Real-Time PCR (qPCR).
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Article
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease
Preprint: Using a newly developed rodent model, the authors assessed whether the intracellular buildup of neuromelanin that occurs with age can be slowed down in vivo to prevent or attenuate Parkinson’s disease. when neuromelanin reaches a specific threshold, it can trigger PD pathology in this animal model.
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Protocol
Intracellular neuromelanin quantification
Protocol for intracellular neuromelanin quantification.
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Protocol
Rat brain processing for histological analyses
Protocol for rat brain processing for histological analyses.
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Protocol
Immunofluorescence on paraffin sections
Protocol for immunofluorescence on paraffin sections.
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Protocol
Determination of free and protein-bound DA and NE and their metabolites and oxidation products by UPLC-MS/MS method
Protocol for the determination of free and protein-bound DA and NE and their metabolites and oxidation products by UPLC-MS/MS method.
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Protocol
Stereology-mediated cell counting using StereoInvestigator
Protocol for stereologic count with StereoInvestigator.
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