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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
The relationship between the activity of dopaminergic neurons (DANs) and the length of movement sequences is unknown. The authors imaged the activity of SNc DANs in mice. Results indicate that movement-initiation DANs encode more than a general motivation signal and invigorate aspects of contralateral movements. View original preprint.
Dataset
Source data for Mendonça et al 2024
Source data and code from dopamine neuron activity encode the length of upcoming contralateral movement sequences by Mendonça et al 2024.
Protocol
Immunofluorescence on paraffin sections
Protocol for immunofluorescence on paraffin sections.
Teams
Protocol
Live tracking of multiple mice in a neuromelanin-inducing PD model over several weeks
The Live Mouse Tracker (LMT) system is engineered for long-term, automated tracking and behavioral analysis of mice, integrating machine learning, computer vision, and RFID technology for simultaneous monitoring of multiple subjects.
Teams
Protocol
Locomotion test for mice
The locomotion test is an open field test in darkness, so it does not aim to measure anxiety, only locomotor activity.
Teams
Teams
Protocol
RNA and protein extraction from bulk dissections
Protocol for RNA and protein extraction from bulk dissections.
Teams
Protocol
Gene expression analysis by qPCR
Protocol for gene expression analysis by quantitative Real-Time PCR (qPCR).
Teams
Protocol
Stereology-mediated cell counting using StereoInvestigator
Protocol for stereologic count with StereoInvestigator.
Teams
Teams
Protocol
Determination of free and protein-bound DA and NE and their metabolites and oxidation products by UPLC-MS/MS method
Protocol for the determination of free and protein-bound DA and NE and their metabolites and oxidation products by UPLC-MS/MS method.
Teams
Teams
Protocol
Rat brain processing for histological analyses
Protocol for rat brain processing for histological analyses.
Teams
Protocol
Intracellular neuromelanin quantification
Protocol for intracellular neuromelanin quantification.
Teams