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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Protocol
Protocols for “Characterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice”
This is a collection of protocols associated to the manuscript “Characterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice.”
Teams
Article
The calcium sensor synaptotagmin-1 is critical for phasic axonal dopamine release in the striatum and mesencephalon, but is dispensable for basic motor behaviors in mice
The authors’ findings reveal the striking resilience of DA-dependent motor functions in the context of a near-abolition of phasic DA release, shedding new light on why extensive loss of DA innervation is required to reveal motor dysfunctions in PD.
Teams
Article
Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes
Preprint: Breach of lysosomes allows mtDNA to access cytosol, requiring multiple Parkinson’s disease-related proteins and Gasdermin pores, identified in the screen. These data place mitochondria-to-lysosome transport as a driver of pyroptosis and link multiple PD proteins along a common pathway.
Teams
Dataset
Single cell transcriptomics from DAT-Cre mouse gut tissue
Colonic myenteric cells were dissociated, and live tdTomato-positive cells were FACS-collected. Colons were isolated from 2 male and female wild type adult DAT-Cre mice. Wild type C57Bl6/J was used as control for gating. Cells were processed according to 10X Genomics Chromium single cell 3′ Reagent guidelines.
Teams
Article
Microbes and Parkinson’s Disease: from associations to mechanisms.
Review: This review dissects the microbial contributions to PD with a particular focus on recent advances and rodent models that can be used for microorganism hypothesis testing.
Teams
Article
LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation
Remarkably, the PD-related protein LRRK2 acted with STING upstream of the UPR to regulate the transition from innate to adaptive immunity, thereby identifying this PD-related protein as a key player in the immune response during inflammation.
Teams
Article
Characterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice
Given the clear heterogeneity of DA gut neurons, further investigation is warranted to define their functional signatures and discover their inherent biological differences that put these cells at risk for neurodegeneration.
Teams
Article
Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice
Taken together, the authors’ findings reveal the striking resilience of DA-dependent motor functions in the context of a near-abolition of phasic DA release, shedding new light on why extensive loss of DA innervation is required to reveal motor dysfunctions in PD.
Teams
Protocol
Protocols for “Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice”
This is a collection of protocols for the manuscript “Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.”
Teams