Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability
By onMisfolded α-synuclein accumulation in PD leads to pathogenic processes. We mapped α-synuclein pathology in mice to identify vulnerable regions and potential therapeutic targets, highlighting group II PAK inhibitors as promising for treating PD.
BugSigDB – Parkinson’s Disease
By onA Comprehensive Database of Published Microbial Signatures in PD
Histology Fushiki et al 2024
By onHistology protocol for Fushiki et al 2024 , to quantify Th+ cells and visualize the dorsal-tier or ventral-tier of SNc DANs.
Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials
By onVariants in the GBA1 gene are common genetic risk factors for Parkinson's disease. A study compared clinical phenotypes in GBA-PD and idiopathic PD patients, finding that only severe GBA-PD cases show a more severe clinical profile.
Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis
By onHeterozygous *GBA1* variants are common in Parkinson's disease. This study found no significant impact of the *GBA1* L444P variant on gut microbiome composition in mice, suggesting other factors may contribute to disease penetrance.
Open Field & Cylinder test Behavior Assays
By onProtocols for mouse behavioral studies using the open field test and the cylinder test from Fushiki et al 2024.
Single-cell RNA-sequencing data from A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
By onSingle-nucleus RNA profiling of the ventral midbrain of MitoPark mice, their littermate controls and C57BL/6 mice at 8, 16, and 24 weeks of age (8 mice in each group; 4 males and 4 females).
Non-human Primate Arm-reaching Behavioral Tasks
By onProtocol for training and testing non-human primates in arm-reaching tasks to evaluate parkinsonian animals
Specific cell states underlie complex tissue regeneration in spiny mice
By onThis paper compares regenerative and fibrotic healing to identify injury-induced cell states associated with persistent cell cycle progression and complex tissue regeneration in mammals.
Key Resource Table for Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses
By onComprehensive key resource table for the publication: "Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses", Mendelsohn et al 2025.
SNr subpopulation neuroanatomy-code
By onMatlab scripts used to plot anatomical data related to the study: Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses.
Quantification tables of SNr molecular organization
By onConfocal image quantification tables associated with the manuscript Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses.
Raw images of SNr molecular anatomy
By onRaw images associated with the manuscript Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses.
Data for Jain et al Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine
By onPrimary data for Jain et al "Adaptor protein-3 produces synaptic vesicles that release phasic dopamine" (Proc Natl Acad Sci. 2023; 120(42):e2309843120. doi: 10.1073/pnas.2309843120)
Slow Release Pellet Implantation
By onThis protocol describes how to subcutaneously implant slow-release pellets into mice.
Striatal Punch Collection
By onThis protocol describes how to collect striatal punches from fresh frozen mouse brain tissue for HPLC analysis.
Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue
By onDevelopment of a 3D model mimicking human brain tissue to investigate neurodegenerative diseases. It found that APOE4 increases α-Synuclein aggregation, linking astrocytes, cholesterol, and protein inclusions, offering potential therapeutic insights.
Advancing Parkinson’s Disease Research: APDA’s Commitment to Innovation
The American Parkinson Disease Association (APDA) highlights Dr. Roberta Marongiu from CRN Team Kaplitt for her work exploring the role of biological sex in Parkinson’s disease.
Immune Cells May Lead to More Parkinson’s Cases in Men
New research from Team Sulzer reveals how a protein in brain cells may drive Parkinson’s onset—and offers a possible explanation for why Parkinson’s is much more common in men.
Molecular Switch for Toxic Protein Disposal May Be Parkinson’s Target
Parkinson's News Today reports on a new study from CRN Team Hurley that identified a molecular switch in a protein complex that regulates how cellular waste disposal mechanisms clean up and recycle unwanted materials - like the toxic alpha-synuclein protein clumps, or aggregates, that drive the death of nerve cells in Parkinson’s disease.
