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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
PINK1 and Parkin: unlocking a mitochondrial quality control pathway linked to Parkinson’s disease
This review focuses on understanding the PINK1/Parkin-mediated mitochondrial quality control pathway through the lens of abherrant immune activation as a driver of dopaminerigic neuron loss following the loss of PINK and Parkin.
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Article
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
Loss-of-function mutations in Parkin cause disruption of mitophagy and are associated with PD. Yet, much of the biology surrounding Parkin function has taken place in artificial cell systems. The authors used human neurons to identify and validate 22 protein targets of Parkin, providing a functional Parkin landscape in neuronal cells.
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Structural basis for the specificity of PPM1H phosphatase for Rab GTPases Figures
Raw data associated with DOI: 10.15252/embr.202152675
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Raw data associated with https://www.biorxiv.org/content/10.1101/2021.02.17.431620v1
Raw data associated with DOI: 10.1101/2021.02.17.431620v1
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Dataset
Raw data associated with DOI: 10.7554/eLife.67900
Raw data associated with DOI: 10.7554/eLife.67900
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Article
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Pathogenic mutations in LRRK2 are known to cause loss of primary cilia in neurons. The authors show that cilia loss is seen very early in mice harboring the most common LRRK2 mutation. Further, they show that this loss of cilia in astrocytes disrupted signaling pathways required for dopamine neuron maintenance. View preprint.
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Article
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
Gain-of-function mutations of LRRK2 are associated with PD. LRRK2 acts by adding a phosphate group to enzymes known as Rab GTPases, which causes new biological events. The authors analyzed the structure of an enzyme, PPM1H, that counteracts LRRK2 by removing the phosphate group it adds to Rab GTPases. View preprint.
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Article
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
Gain-of-function mutations of LRRK2 are associated with PD. LRRK2 acts by adding a phosphate group to enzymes known as Rab GTPases, which causes new biological events. The authors analyzed the structure of an enzyme, PPM1H, that counteracts LRRK2 by removing the phosphate group it adds to Rab GTPases. View preprint.
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