Targeted long-read RNA-seq
By onTargeted long-read RNAseq of SNCA, GBA1, and GBAP1. Three datasets are available: (i) human brain (ii) iPSC-derived astrocytes microglia neurons and (iii) iPSC-derived midbrain dopaminergic neurons.
Parkinson’s Disease MAGMA Analysis Ranked Genes
By onGWAS summary statistics for PD risk were obtained and processed using the MAGMA tool on FUMA’s online platform to generate a scored list (z-scores) of significant genes.
MERFISH Dataset of Mouse Dopamine Neurons
By onMERFISH runs of mouse Midbrain spatial transcriptomics
Primary data associated with the manuscript “Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease” (doi: 10.1073/pnas.2402206121)
By onPrimary data (RNA sequencing; microscopy& imaging) for the manuscript (doi: 10.1073/pnas.2402206121), including a ReadMe file (with description of the data and file structure).
snRNA data from Gaertner & Oram et al., 2024
By onDAT-Cre mice with a nuclear GFP reporter and either WT or heterozygous G2019S mutant alleles for the gene Lrrk2. Samples contain tissue from midbrains after isolation of DAT+ nuclei via microfluidic sorting for GFP.
ASAP Parkinson Cell Atlas in 5D (PD5D)
By onThe PD5D Atlas deciphers Parkinson's disease molecular blueprint using brain space, disease stage, and cell types dimensions. It includes various omics data and clinical scales to analyze PD progression from healthy aging to Lewy body neuropathology.
Translating ribosome affinity purification analysis of dopaminergic neurons of the mouse ventral midbrain with age and alpha-synuclein overexpression
By onComparative gene expression profiling analysis of RNA-seq data for DAT-TRAP samples in 3- and 18-month old mice, with and without human alpha-synuclein overexpression.
Stereo-seq raw data of the mouse ventral midbrain with age and alpha-synuclein overexpression
By onStereo-seq raw data from 3- and 18-month old mice, with and without human alpha-synuclein overexpression.
Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology Dataset: raw sequencing files
By onSpatial Transcriptomics data in pathology bearing neurons of PFF injected mice and Parkinson's disease human post mortem brain.
Transcriptomic analysis of colonic lamina propria cells in PINK1 KO mice compared to wild type following intestinal microbial infection
By onTranscriptomic analysis of colonic lamina propria cells in PINK1 KO mice compared to wild type following intestinal microbial infection
RNA Seq dataset for: α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
By onActively transcribed messenger ribonucleic acids (mRNAs) were harvested from SNc dopaminergic neurons in aSYN monomer or PFF-injected mice 12 weeks post injection and then subjected to RNASeq analysis.
Key Resource Table for Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses
By onComprehensive key resource table for the publication: "Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses", Mendelsohn et al 2025.
Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses I
By onThis dataset provides a unifying logic for how the developmental specification of diverse SNr neurons relates to the anatomical organization of basal ganglia circuits controlling specialized downstream brain regions.
Single nucleus RNA sequencing of SNr neurons
By onThese findings provide a unifying logic for how the developmental specification of diverse SNr neurons relates to the anatomical organization of basal ganglia circuits controlling specialized downstream brain regions.
Single-cell RNA-sequencing data from A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
By onSingle-nucleus RNA profiling of the ventral midbrain of MitoPark mice, their littermate controls and C57BL/6 mice at 8, 16, and 24 weeks of age (8 mice in each group; 4 males and 4 females).
Developing Allelic Imbalance Analysis from Single-Nucleus RNA-Seq Data
By onAllele-specific expression (ASE) analysis in single-nucleus RNA-seq (snRNA-Seq) helps study genetic variation impact on RNA expression. Experimental and computational choices can enhance ASE analysis results.
Palumbos_LRRK2G2019S_CTRL_Secretome_smRNA_Transcriptomics
By onSmall RNA transcriptomic data profiling secretome of control and LRRK2(G2019S) murine cortical neurons.
RNAseq data associated with Moiseyenko et al. 2025
By onBAM files for RNA sequencing of large intestine of wild-type, Thy1-ASO, and Faecalibacterium prausnitzii-treated Thy1-ASO mice from Moiseyenko et al. (2025)
Transcriptomic analysis of colonic lamina propria cells in LRRK2 G2019S mice compared to wild type following intestinal microbial infection
By onUsing scRNAseq and flow cytometry, we demonstrated that the Lrrk2 G2019S mutation is associated with an increased neutrophil presence in the colonic lamina propria during infection and a Th17 skewing, upregulated Il17a, and greater colonic pathology
Bulk RNAseq of microglia in vitro cultures
By onBulk RNAseq data of human pluripotent stem cells differentiated into microglia was generated using Illumina TruSeq kit. Cells were induced through mesodermal and myeloid differentiation to produce microglia-like cells, mimicking human microglia.
