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Output Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

  results for "Team Chen"
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Available ASAP-related hPSC collection from Team Studer

Collection of human pluripotent stem cell lines consisting of isogenic GBA, LRRK2, SNCA series, KI-reporter lines for TOMM20, b-actin, LAMB1, LAMP1, a-synuclein overexpression lines, and other hPSC resources.

Program: Collaborative Research Network
Team:
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Collection of protocols of Team Deleidi used in the publication: “”LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease””

Collection of protocols of Team Deleidi used in the publication: ""LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease""

Program: Collaborative Research Network
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Image Processing and 3D Reconstruction – Chen et al. 2025 NSMB

Image processing and 3D reconstruction applied in Chen et al. 2025 NSMB

Program: Collaborative Research Network
Team:
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LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3

The Leucine-rich repeat kinase-2 (LRRK2) G2019S mutation, resulting in aberrantly enhanced kinase activity, is one of the well-recognized genetic risk factors in Parkinson’s Disease (PD). Increased LRRK2 activity was also observed in immune…

Program: Collaborative Research Network
Team:
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Plasmid construction – Chen et al. 2025 NSMB

Standard cloning procedure.

Program: Collaborative Research Network
Team:
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Multi-ancestry genome-wide meta-analysis in Parkinson’s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, all studies have been performed in just one population at the time. Here we performed the first large-scale…

Program: Global Parkinson's Genetics Program
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Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson’s disease

Objective This study aims to address disparities in risk prediction by evaluating the performance of polygenic risk score (PRS) models using the 90 risk variants across 78 independent loci previously linked to Parkinson’s disease (PD) risk across…

Program: Global Parkinson's Genetics Program
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Human Postmortem-Derived Brain Sequencing Collection (Harmonized Collection)

The Human Postmortem-derived Brain Sequencing Collection is a harmonized repository comprised of sequencing data contributed by ASAP CRN teams.

Program: Collaborative Research Network
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Collection of protocols for paper: “Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function”

This is a collection of protocols used in a recent preprint by the Deleidi Lab, Team Schapira. You can access pre-print at https://doi.org/10.21203/rs.3.rs-1521848/v1

Program: Collaborative Research Network
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Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

The authors demonstrate an essential role of the pore-containing subunit TOM40 and its structurally associated subunits TOM7 and TOM22 for PINK1 activation.

Program: Collaborative Research Network
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Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson’s Disease

This preprint explores immune factors in Parkinson's disease linked to LRRK2 mutations. Serum showed elevated SDF-1 alpha and TNF-RII levels in LRRK2 carriers, while CSF had reduced immune markers. PD patients displayed reduced CSF inflammation.

Program: Collaborative Research Network
Team:
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AAV Purification Protocol with Iodixanol gradient

Protocol used in the Kaplitt and Marongiu labs to purify AAVs.

Program: Collaborative Research Network
Team:
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Validation of Genotyping Method for L444P Mice Ear-Clips.

|| Team Schapira || Authors Revi Shahar Golan, David Chau Abstract Aim: the genotyping is used to identify if mice are heterozygote (hetero) or Wild-Type (WT), and the aim of the work is to validate the digestion method, and PCR program, the PCR…

Program: Collaborative Research Network
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BugSigDB – Parkinson’s Disease

A Comprehensive Database of Published Microbial Signatures in PD

Program: Collaborative Research Network
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Regional Mouse Brain Analysis (Modified QUINT)

This is series of protocols that has been adapted from published and unpublished protocols broadly referred to as the QUINT workflow: QuPath visualization/segmentation QuickNII Brain Atlas Registration QMask Hemispheric Separation Visualign…

Program: Collaborative Research Network
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