Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

The pathogenesis of Parkinson’s disease

This review is the second in a series of three papers about Parkinson’s disease published in the Lancet.

Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation

A STAR protocol that describes how to differentiate cryopreserved human cortical neuronal progenitors into mature cortical neurons for high-throughput imaging analysis.

Protocol

Preparation of human iPSC-derived cortical neuronal progenitors for transplantation into the rodent brain

This protocol describes how the authors prepare human iPSC-derived cells, that have been differentiated into cortical neuronal progenitors, for transplantation into the brain of immunocompromised athymic mice. Neuronal progenitors mature within the mouse brain and are used to study the pathogenesis of Parkinson’s disease.

Generation of the iPSC line FINi002-A from a male Parkinson’s disease patient carrying compound heterozygous mutations in the PRKN gene

This article describes the generation of the iPSC line FINi002-A from a male Parkinson’s disease patient carrying compound heterozygous mutations in the PRKN gene.

Protocol

Free-floating immunofluorescence protocol on mouse brain sections for tau pathology

This protocol describes the free-floating multiplexed immunofluorescent staining protocol to ascertain levels of tau and phospho-tau in mouse tissue from transplanted human iPSC cells carrying different PD-related mutations.